Virus vaccine from the strain “La-Sota” against Newcastle disease dry
Purpose:
The vaccine is intended for prevention of the Newcastle disease in favorable, under the thread and unfavorable breeding farms and commercial poultry farms of various line of farming.
Description and characteristic:
In appearance, the vaccine is a dry porous mass of light-yellow or light-brown color, easily soluble in distilled water or physiological saline without the formation of flakes and/or sediment. The vaccine is produced from extraembryonic liquid of SPF-chicken embryos infected with the attenuated Newcastle disease virus (the strain «La-Sota») lyophilized in a protective environment.
Method of vaccination:
The vaccine is administered to the poultry intranasally, peroral, aerosol and spray-method. Starting date of vaccination is established based on the level of maternal antibodies in chickens of 7-10-day-old, testing at least 25 samples of blood sera of poultry placed in one poultry house (room) in the hemagglutination-inhibition test or the ELISA. The vaccination should be implemented if 20% of the sera samples or more have the titer of antibodies towards the Newcastle disease virus in the hemagglutination-inhibition test below 1:8 or in the ELISA, it is lower than the double positive value indicated. If 80% of the sera samples and more have the titer of antibodies towards the Newcastle disease virus in the hemagglutination-inhibition test 1:8 and above, and in the ELISA it two and more times exceeds the positive value, poultry should be examined again every 3-5 days and in the case of easing of the immune response till 80% vaccination should be implemented. Assume that 1 enteral dose is equal to 1 intranasal dose.
Immune response:
The vaccine provokes the formation of immune response in poultry toward the causative agent of Newcastle disease at 7-8 days after single application. The immune response has duration of 1.5-2 months.
Production form:
The vaccine is packaged into 2-4 cm3 (100-5000 intranasal doses) bottles of suitable capacity.
Storage and transportation conditions:
The vaccine is stored and transported in a dark place at a temperature from 2 to 8ºС.
Shelf life -12 months.